IUBMB Enzyme Nomenclature


Accepted name: (S)-3,5-dihydroxyphenylglycine transaminase

Reaction: (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate

Glossary: (S)-3,5-dihydroxyphenylglycine = (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid

Other name(s): HpgT

Systematic name: (S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase

Comments: A pyridoxal-5′-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H. Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin. Chem. Comm. (2001) 1252-1253.

[EC created 2013]

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