Reaction: dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-α-D-hexopyranose + L-glutamate
For diagram of reaction click here.
Other name(s): SpnR; TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase
Systematic name: dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
References:
1. Hong, L., Zhao, Z., Melancon, C.E., 3rd, Zhang, H. and Liu, H.W. In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa, J. Am. Chem. Soc. 130 (2008) 4954-4967. [PMID: 18345667]