Reaction: spermidine + 8-amino-7-oxononanoate = N-(3-aminopropyl)-4-aminobutanal + 7,8-diaminononanoate
Other name(s): BIO3-BIO1 (gene name)
Systematic name: spermidine:8-amino-7-oxononanoate aminotransferase
Comments: A pyridoxal 5′-phosphate enzyme. The enzyme, characterized from the plant Arabidopsis thaliana, differs from enzymes that catalyse a similar reaction by using spermidine as the amino group donor. The enzyme from Arabidopsis thaliana is bifunctional and also catalyses EC 6.3.3.3, dethiobiotin synthase. cf. EC 2.6.1.62, adenosylmethionine—8-amino-7-oxononanoate transaminase, and EC 2.6.1.105, lysine—8-amino-7-oxononanoate transaminase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Noble, C.G., Hollinshead, T., Kende, A., Langford, M.P., Lim, P.P., Linney, E., Mattocks, J., Swindale, L.Y. and Green, K. The plant Diaminopelargonic acid aminotransferase uses spermidine as its amino donor. Plant J. 121 (2025) e70076. [PMID: 40028677]