IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxyglutamate transaminase

Reaction: erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate

For diagram of reaction, click here and for mechanism, click here

Glossary: erythro-4-hydroxy-L-glutamate = (2S,4R)-2-amino-4-hydroxypentanedioate

Other name(s): 4-hydroxyglutamate aminotransferase; 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase

Systematic name: erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase

Comments: The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC aspartate transaminase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37277-86-4


1. Goldstone, A. and Adams, E. Metabolism of γ-hydroxyglutamic acid. I. Conversion to α-hydroxy-γ-ketoglutarate by purified glutamic-aspartic transaminase to rat liver. J. Biol. Chem. 237 (1962) 3476-3485. [PMID: 13948827]

2. Kuratomi, K., Fukunaga, K. and Kobayashi, Y. The metabolism of γ-hydroxyglutamate in rat liver. II. A transaminase concerned in γ-hydroxyglutamate metabolism. Biochim. Biophys. Acta 78 (1963) 629-636. [PMID: 14089443]

3. Maitra U, Deekker E Purification of rat-liver γ-hydroxyglutamate transaminase and its probable identity with glutamate-aspartate transaminase. Biochim. Biophys. Acta 81 (1964) 517-532. [PMID: 14170323]

[EC created 1972, modified 1982, modified 2020]

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