Reaction: L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate
For diagram click here.
Glossary: (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine
L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate
Other name(s): lysine 6-aminotransferase; lysine ε-aminotransferase; lysine ε-transaminase; lysine:2-ketoglutarate 6-aminotransferase; L-lysine-α-ketoglutarate aminotransferase; L-lysine-α-ketoglutarate 6-aminotransferase
Systematic name: L-lysine:2-oxoglutarate 6-aminotransferase
Comments: A pyridoxal-phosphate protein. The product (allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9054-68-6
References:
1. Soda, K., Misono, H. and Yamamoto, T. L-Lysine:α-ketoglutarate aminotransferase. I. Identification of a product, δ-1-piperideine-6-carboxylic acid. Biochemistry 7 (1968) 4102-4109. [PMID: 5722275]
2. Soda, K. and Misono, H. L-Lysine: α-ketoglutarate aminotransferase. II. Purification, crystallization, and properties. Biochemistry 7 (1968) 4110-4119. [PMID: 5722276]