IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxyethylphosphonate cytidylyltransferase

Reaction: 2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate

Other name(s): Fom1

Systematic name: CTP:2-hydroxyethylphosphonate cytidylyltransferase

Comments: The enzyme, isolated from the bacterium Streptomyces wedmorensis, is involved in fosfomycin biosynthesis. The enzyme also is active as EC phosphoenolpyruvate mutase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Cho, S.H., Kim, S.Y., Tomita, T., Shiraishi, T., Park, J.S., Sato, S., Kudo, F., Eguchi, T., Funa, N., Nishiyama, M. and Kuzuyama, T. Fosfomycin biosynthesis via transient cytidylylation of 2-hydroxyethylphosphonate by the bifunctional Fom1 enzyme. ACS Chem. Biol. 12 (2017) 2209-2215. [PMID: 28727444]

[EC created 2020]

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