IUBMB Enzyme Nomenclature


Accepted name: D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase

Reaction: D-glycero-α-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-α-D-manno-heptose + diphosphate

Other name(s): hddC (gene name); gmhD (gene name)

Systematic name: GTP:D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase

Comments: The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P. and Messner, P. Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose. J. Biol. Chem. 276 (2001) 20935-20944. [PMID: 11279237]

[EC created 2010]

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