IUBMB Enzyme Nomenclature


Accepted name: tRNA-5-taurinomethyluridine 2-sulfurtransferase

Reaction: a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouridine34 in tRNA + AMP + diphosphate + acceptor

Other name(s): MTU1 (gene name); SLM3 (gene name); MTO2 (gene name)

Systematic name: [protein]-S-sulfanyl-L-cysteine:tRNA (5-taurinomethyluridine34 2-O)-sulfurtransferase

Comments: The enzyme, found in mitochondria, catalyses formation of 5-taurinomethyl-2-thiouridine in the wobble position of mitochondrial tRNAGln, tRNALys and tRNAGlu.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Umeda, N., Suzuki, T., Yukawa, M., Ohya, Y., Shindo, H., Watanabe, K. and Suzuki, T. Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J. Biol. Chem. 280 (2005) 1613-1624. [PMID: 15509579]

2. Wang, X., Yan, Q. and Guan, M.X. Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. FEBS Lett. 581 (2007) 4228-4234. [PMID: 17706197]

[EC created 2015]

Return to EC 2.8.1 home page
Return to EC 2.8 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page