IUBMB Enzyme Nomenclature


Accepted name: L-aspartate semialdehyde sulfurtransferase

Reaction: hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster

Other name(s): MA1821 (locus name); MJ0100 (locus name)

Systematic name: hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase

Comments: The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Rauch, B.J., Gustafson, A. and Perona, J.J. Novel proteins for homocysteine biosynthesis in anaerobic microorganisms. Mol. Microbiol. 94 (2014) 1330-1342. [PMID: 25315403]

2. Allen, K.D., Miller, D.V., Rauch, B.J., Perona, J.J. and White, R.H. Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea. Biochemistry 54 (2015) 3129-3132. [PMID: 25938369]

[EC created 2019]

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