IUBMB Enzyme Nomenclature


Accepted name: L-aspartate semialdehyde sulfurtransferase

Reaction: hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster

Other name(s): MA1821 (locus name); MJ0100 (locus name)

Systematic name: hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase

Comments: The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.


1. Rauch, B.J., Gustafson, A. and Perona, J.J. Novel proteins for homocysteine biosynthesis in anaerobic microorganisms. Mol. Microbiol. 94 (2014) 1330-1342. [PMID: 25315403]

2. Allen, K.D., Miller, D.V., Rauch, B.J., Perona, J.J. and White, R.H. Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea. Biochemistry 54 (2015) 3129-3132. [PMID: 25938369]

[EC created 2019]

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