Reaction: a [protein]-S-sulfanyl-L-cysteine + sulfoacetaldehyde + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ = a [protein]-L-cysteine + coenzyme M + 4 oxidized ferredoxin [iron-sulfur] cluster
Glossary: coenzyme M = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate
Other name(s): comF (gene name); MJ1681 (locus name)
Systematic name: [protein]-S-sulfanyl-L-cysteine:sulfoacetaldehyde sulfurtransferase
Comments: The enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses the last step in the biosynthesis of coenzyme M. The enzyme carries two [4Fe-4S] clusters. The reaction involves two L-cysteine residues, one of which receives a sulfane sulfur from a donor protein.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. White, R.H. Identification of an enzyme catalyzing the conversion of sulfoacetaldehyde to 2-mercaptoethanesulfonic acid in methanogens. Biochemistry 58 (2019) 1958-1962. [PMID: 30932481]