IUBMB Enzyme Nomenclature


Accepted name: thiosulfate—thiol sulfurtransferase

Reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide

Other name(s): glutathione-dependent thiosulfate reductase; sulfane reductase; sulfane sulfurtransferase

Systematic name: thiosulfate:thiol sulfurtransferase

Comments: The primary product is glutathione hydrodisulfide, which reacts with glutathione to give glutathione disulfide and sulfide. L-Cysteine can also act as acceptor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 111070-24-7


1. Peck, H.D. and Fischer, E. The oxidation of thiosulfate and phosphorylation in extracts of Thiobacillus thioparus. J. Biol. Chem. 237 (1962) 190-197.

2. Sido, B. and Koj, A. Separation of rhodanese and thiosulfate reductase activities in carp liver extracts. Acta Biol. Cracow Ser. Zoo. 15 (1972) 97-103.

3. Uhteg, L.C. and Westley, J. Purification and steady-state kinetic analysis of yeast thiosulfate reductase. Arch. Biochem. Biophys. 195 (1979) 211-222. [PMID: 383018]

[EC created 1982]

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