IUBMB Enzyme Nomenclature


Accepted name: cortisol sulfotransferase

Reaction: 3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate

Glossary: 3'-phosphoadenylyl sulfate = PAPS

Other name(s): glucocorticosteroid sulfotransferase; glucocorticoid sulfotransferase; 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase

Systematic name: 3'-phosphoadenylyl-sulfate:cortisol 21-sulfonotransferase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 59782-20-6


1. Singer, S.S. and Brill, B. Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol. Biochim. Biophys. Acta 712 (1982) 590-596. [PMID: 6957246]

2. Singer, S.S., Giera, D., Johnson, J. and Sylvester, S. Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations. Endocrinology 98 (1976) 963-974. [PMID: 1278101]

[EC created 1986]

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