IUBMB Enzyme Nomenclature


Accepted name: alcohol sulfotransferase

Reaction: 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate

Glossary: 3'-phosphoadenylyl sulfate = PAPS

Other name(s): hydroxysteroid sulfotransferase; 3β-hydroxy steroid sulfotransferase; δ5-3β-hydroxysteroid sulfokinase; 3-hydroxysteroid sulfotransferase; HST; 5α-androstenol sulfotransferase; cholesterol sulfotransferase; dehydroepiandrosterone sulfotransferase; estrogen sulfokinase; estrogen sulfotransferase; steroid alcohol sulfotransferase; steroid sulfokinase; steroid sulfotransferase; sterol sulfokinase; sterol sulfotransferase; alcohol/hydroxysteroid sulfotransferase; 3β-hydroxysteroid sulfotransferase; 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase

Systematic name: 3'-phosphoadenylyl-sulfate:alcohol sulfonotransferase

Comments: Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC steroid sulfotransferase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9032-76-2


1. Lyon, E.S. and Jakoby, W.B. The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases. Arch. Biochem. Biophys. 202 (1980) 474-481. [PMID: 6935986]

2. Lyon, E.S., Marcus, C.J., Wang, J.-L. and Jakoby, W.B. Hydroxysteroid sulfotransferase. Methods Enzymol. 77 (1981) 206-213. [PMID: 6173569]

[EC created 1961, modified 1980]

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