IUBMB Enzyme Nomenclature


Accepted name: trehalose 2-sulfotransferase

Reaction: 3'-phosphoadenylyl sulfate + α,α-trehalose = adenosine 3',5'-bisphosphate + 2-O-sulfo-α,α-trehalose

Glossary: 2-O-sulfo-α,α-trehalose = trehalose 2-sulfate = α-D-glucopyranosyl 2-O-sulfo-α-D-glucopyranoside

Other name(s): Stf0 sulfotransferase; 3'-phosphoadenylyl-sulfate:α,α-trehalose 2-sulfotransferase

Systematic name: 3'-phosphoadenylyl-sulfate:α,α-trehalose 2-sulfonotransferase

Comments: The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Mougous, J.D., Petzold, C.J., Senaratne, R.H., Lee, D.H., Akey, D.L., Lin, F.L., Munchel, S.E., Pratt, M.R., Riley, L.W., Leary, J.A., Berger, J.M. and Bertozzi, C.R. Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat. Struct. Mol. Biol. 11 (2004) 721-729. [PMID: 15258569]

2. Pi, N., Hoang, M.B., Gao, H., Mougous, J.D., Bertozzi, C.R. and Leary, J.A. Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry. Anal. Biochem. 341 (2005) 94-104. [PMID: 15866533]

[EC created 2014]

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