IUBMB Enzyme Nomenclature


Accepted name: succinate—hydroxymethylglutarate CoA-transferase

Reaction: succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + (S)-3-hydroxy-3-methylglutaryl-CoA

Systematic name: succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase

Other names: hydroxymethylglutarate coenzyme A-transferase; dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase

Comments: Malonyl-CoA can also act as donor, but more slowly.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 80237-90-7


1. Deana, R., Rigoni, F., Deana, A.D.and Galzigna, L. Submitochondrial localization and partial purification of the succinyl CoA: 3-hydroxy-3-methylglutarate coenzyme A transferase from rat liver. Biochim. Biophys. Acta 662 (1981) 119-124. [PMID: 6946836]

[EC created 1984]

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