IUBMB Enzyme Nomenclature


Accepted name: bile acid CoA-transferase

Reaction: (1) lithocholoyl-CoA + cholate = lithocholate + choloyl-CoA
(2) deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA

Other name(s): baiF (gene name); baiK (gene name); bile acid coenzyme A transferase

Systematic name: lithocholoyl-CoA:cholate CoA-transferase

Comments: The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7α-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. The enzyme has a broad substrate specificity and can use multiple acceptors, including allocholate, ursodeoxycholate, and β-muricholate.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Ridlon, J.M. and Hylemon, P.B. Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium. J. Lipid Res. 53 (2012) 66-76. [PMID: 22021638]

[EC created 2005 as EC, transferred 2016 to EC]

Return to EC 2.8.3 home page
Return to EC 2.8 home page
Return to EC 2 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page