IUBMB Enzyme Nomenclature


Accepted name: succinyl-CoA:mesaconate CoA transferase

Reaction: succinyl-CoA + mesaconate = 2-methylfumaryl-CoA + succinate

Glossary: 2-methylfumaryl-CoA = (E)-3-carboxy-2-methylprop-2-enoyl-CoA
mesaconate = 2-methylbut-2-enedioic acid

Other name(s): mct (gene name)

Systematic name: succinyl-CoA:mesaconate CoA transferase

Comments: The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Khomyakova, M., Bukmez, O., Thomas, L.K., Erb, T.J. and Berg, I.A. A methylaspartate cycle in haloarchaea. Science 331 (2011) 334-337. [PMID: 21252347]

2. Borjian, F., Johnsen, U., Schonheit, P. and Berg, I.A. Succinyl-CoA:mesaconate CoA-transferase and mesaconyl-CoA hydratase, enzymes of the methylaspartate cycle in Haloarcula hispanica. Front. Microbiol. 8 (2017) 1683. [PMID: 28932214]

[EC created 2020]

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