IUBMB Enzyme Nomenclature


Accepted name: phenylsuccinyl-CoA transferase

Reaction: (1) phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate
(2) phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate

Other name(s): iaaL (gene name)

Systematic name: succinyl-CoA:2/3-phenylsuccinate CoA-transferase

Comments: The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Schuhle, K., Nies, J. and Heider, J. An indoleacetate-CoA ligase and a phenylsuccinyl-CoA transferase involved in anaerobic metabolism of auxin. Environ. Microbiol. 18 (2016) 3120-3132. [PMID: 27102732]

[EC created 2022]

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