IUBMB Enzyme Nomenclature


Accepted name: 5-phospho-D-xylono-1,4-lactonase

Reaction: (1) D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate
(2) L-arabino-1,4-lactone 5-phosphate + H2O = 5-phospho-L-arabinate

Systematic name: 5-phospho-D-xylono-1,4-lactone hydrolase

Comments: The enzyme, characterized from Mycoplasma spp., contains a binuclear metal center with two zinc cations. The enzyme is specific for the phosphorylated forms, and is unable to hydrolyse non-phosphorylated 1,4-lactones.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Korczynska, M., Xiang, D.F., Zhang, Z., Xu, C., Narindoshvili, T., Kamat, S.S., Williams, H.J., Chang, S.S., Kolb, P., Hillerich, B., Sauder, J.M., Burley, S.K., Almo, S.C., Swaminathan, S., Shoichet, B.K. and Raushel, F.M. Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate. Biochemistry 53 (2014) 4727-4738. [PMID: 24955762]

[EC created 2018]

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