IUBMB Enzyme Nomenclature


Accepted name: sn-1-specific diacylglycerol lipase

Reaction: a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid

Other name(s): DAGLA (gene name); DAGLB (gene name)

Systematic name: diacylglycerol sn-1-acylhydrolase

Comments: The enzyme, present in animals, is specific for the sn-1 position. When acting on 1-acyl-2-arachidonoyl-sn-glycerol, the enzyme forms 2-arachidonoylglycerol, the most abundant endocannabinoid in the mammalian brain.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Chau, L.Y. and Tau, H.H. Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase. Biochem. Biophys. Res. Commun. 100 (1988) 1688-1695. [PMID: 7295321]

2. Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M.G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E.J., Gangadharan, U., Hobbs, C., Di Marzo, V. and Doherty, P. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell Biol. 163 (2003) 463-468. [PMID: 14610053]

3. Bisogno, T. Assay of DAGLα/β activity. Methods Mol. Biol. 1412 (2016) 149-156. [PMID: 27245901]

[EC created 2021]

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