IUBMB Enzyme Nomenclature


Accepted name: phospholipase A1

Reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate

Systematic name: phosphatidylcholine 1-acylhydrolase

Comments: This enzyme has a much broader specificity than EC phospholipase A2. Requires Ca2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9043-29-2


1. Gatt, S. Purification and properties of phospholipase A-1 from rat and calf brain. Biochim. Biophys. Acta 159 (1968) 304-316. [PMID: 5657461]

2. Scandella, C.J. and Kornberg, A. A membrane-bound phospholipase A1 purified from Escherichia coli. Biochemistry 10 (1971) 4447-4456. [PMID: 4946924]

3. van den Bosch, H. Intracellular phospholipases A. Biochim. Biophys. Acta 604 (1980) 191-246. [PMID: 6252969]

4. van den Bosch, H., Aarsman, A.J. and van Deenen, L.L.M. Isolation and properties of a phospholipase A1 activity from beef pancreas. Biochim. Biophys. Acta 348 (1974) 197-209. [PMID: 4858811]

[EC created 1972, modified 1976]

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