IUBMB Enzyme Nomenclature


Accepted name: phorbol-diester hydrolase

Reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate

For reaction pathway click here.

Other name(s): diacylphorbate 12-hydrolase; diacylphorbate 12-hydrolase; phorbol-12,13-diester 12-ester hydrolase; PDEH

Systematic name: 12,13-diacylphorbate 12-acylhydrolase

Comments: Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 81181-74-0


1. Shoyab, M., Warren, T.C. and Todaro, G.J. Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver. J. Biol. Chem. 256 (1981) 12529-12534. [PMID: 6946062]

[EC created 1984]

Return to EC 3.1.1 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page