Reaction: acetylcholine + H2O = choline + acetate
Other name(s): true cholinesterase; choline esterase I; cholinesterase; acetylthiocholinesterase; acetylcholine hydrolase; acetyl.β-methylcholinesterase; AcCholE
Systematic name: acetylcholine acetylhydrolase
Comments: Acts on a variety of acetic esters; also catalyses transacetylations.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9000-81-1
References:
1. Augustinsson, K.-B. Cholinesterases. A study in comparative enzymology. Acta Physiol. Scand. 15, Suppl. 52 (1948).
2. Bergmann, F., Rimon, S. and Segal, R. Effect of pH on the activity of eel esterase towards different substrates. Biochem. J. 68 (1958) 493-499.
3. Cilliv, G. and Ozand, P.T. Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior. Biochim. Biophys. Acta 284 (1972) 136-156. [PMID: 5073758]
4. Leuzinger, W., Baker, A.L. and Cauvin, E. Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point. Proc. Natl. Acad. Sci. USA 59 (1968) 620-623. [PMID: 5238989]
5. Nachmansohn, D. and Wilson, I.B. The enzymic hydrolysis and synthesis of acetylcholine. Adv. Enzymol. Relat. Subj. Biochem. 12 (1951) 259-339.
6. Zittle, C.A., DellaMonica, E.S., Custer, J.H. and Krikorian, R. Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction. Arch. Biochem. Biophys. 56 (1955) 469-475.