Reaction: mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate
Glossary: mycophenolate = (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
mycophenolic acid O-acyl-glucuronide = 1-O-[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoyl]-β-D-glucopyranuronic acid
Other name(s): mycophenolic acid acyl-glucuronide deglucuronidase; AcMPAG deglucuronidase
Systematic name: mycophenolic acid O-acyl-glucuronide-ester hydrolase
Comments: This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate that is thought to be immunotoxic.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Iwamura, A., Fukami, T., Higuchi, R., Nakajima, M. and Yokoi, T. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. J. Biol. Chem. 287 (2012) 9240-9249. [PMID: 22294686]