IUBMB Enzyme Nomenclature


Accepted name: methylated diphthine methylhydrolase

Reaction: diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol

For diagram of reaction click here.

Glossary: diphthine methyl ester = 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine
diphthine = 2-[(3S)-3-carboxy-3-(trimethylammonio)propyl]-L-histidine

Other name(s): Dph7; diphthine methylesterase (incorrect)

Systematic name: diphthine methyl ester acylhydrolase

Comments: The protein is only present in eukaryotes.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Lin, Z., Su, X., Chen, W., Ci, B., Zhang, S. and Lin, H. Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. J. Am. Chem. Soc. 136 (2014) 6179-6182. [PMID: 24739148]

[EC created 2014, modified 2015]

Return to EC 3.1.1 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page