IUBMB Enzyme Nomenclature


Accepted name: exodeoxyribonuclease I

Reaction: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

Other name(s): Escherichia coli exonuclease I; E. coli exonuclease I; exonuclease I

Comments: Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9037-46-1


1. Blakesley, R.W., Dodgson, J.B., Nes, I.F. and Wells, R.D. Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius. J. Biol. Chem. 252 (1977) 7300-7306. [PMID: 71298]

2. Kelley, R.B., Atkinson, M.R., Huberman, J.A. and Kornberg, A. Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli. Nature 224 (1969) 495-501.

3. Lehman, I.R. and Nussbaum, A.L. The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase). J. Biol. Chem. 239 (1964) 2628-2636.

[EC created 1972 as EC, transferred 1978 to EC]

Return to EC 3.1.11 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page