Reaction: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Other name(s): Escherichia coli exonuclease III; E. coli exonuclease III; endoribonuclease III
Comments: Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA. Formerly EC 3.1.4.27.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9037-44-9
References:
1. Lindahl, T., Gally, J.A. and Edelman, G.M. Properties of deoxyribonuclease 3 from mammalian tissues. J. Biol. Chem. 244 (1969) 5014-5019. [PMID: 5824576]
2. Richardson, C.C. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity. J. Biol. Chem. 239 (1964) 242-250.
3. Richardson, C.C., Lehman, I.R. and Kornberg, A. A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity. J. Biol. Chem. 239 (1964) 251-258.