IUBMB Enzyme Nomenclature


Accepted name: exodeoxyribonuclease (phage SP3-induced)

Reaction: Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates

Other name(s): phage SP3 DNase; DNA 5'-dinucleotidohydrolase; deoxyribonucleate 5'-dinucleotidase; deoxyribonucleic 5'-dinucleotidohydrolase; bacteriophage SP3 deoxyribonuclease; deoxyribonucleate 5'-dinucleotidase

Comments: Preference for single-stranded DNA. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Trilling, D.M. and Aposhian, H.V. Sequential cleavage of dinucleotides from DNA by phage Sp3 DNAse. Proc. Natl. Acad. Sci. USA 60 (1968) 214-221. [PMID: 4968633]

[EC created 1972 as EC, transferred 1978 to EC]

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