IUBMB Enzyme Nomenclature


Accepted name: exoribonuclease H

Reaction: 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid

Comments: This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC (retroviral ribonuclease H).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Schatz, O., Mous, J. and Le Grice, S.F. HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'—5' exonuclease activity. EMBO J. 9 (1990) 1171-1176. [PMID: 1691093]

[EC created 1978, modified 2010]

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