IUBMB Enzyme Nomenclature


Accepted name: S-formylglutathione hydrolase

Reaction: S-formylglutathione + H2O = glutathione + formate

Systematic name: S-formylglutathione hydrolase

Comments: Also hydrolyses S-acetylglutathione, but more slowly.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 83380-83-0


1. Uotila, L. Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases. Biochemistry 12 (1973) 3938-3943. [PMID: 4200890]

2. Uotila, L. and Koivusalo, M. Purification and properties of S-formylglutathione hydrolase from human liver. J. Biol. Chem. 249 (1974) 7664-7672. [PMID: 4436331]

3. Harms, N., Ras, J., Reijnders, W.N., van Spanning, R.J. and Stouthamer, A.H. S-Formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification? J. Bacteriol. 178 (1996) 6296-6299. [PMID: 8892832]

[EC created 1978]

Return to EC 3.1.2 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page