IUBMB Enzyme Nomenclature


Accepted name: (3S)-malyl-CoA thioesterase

Reaction: (S)-malyl-CoA + H2O = (S)-malate + CoA

Glossary: (S)-malate = (2S)-2-hydroxybutanedioate
(S)-malyl-CoA = (3S)-3-carboxy-3-hydroxypropanoyl-CoA

Other name(s): mcl2 (gene name)

Systematic name: (S)-malyl-CoA hydrolase

Comments: Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC, malyl-CoA lyase) or other CoA esters.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Erb, T.J., Frerichs-Revermann, L., Fuchs, G. and Alber, B.E. The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-malyl-coenzyme A (CoA)/β-methylmalyl-CoA lyase and (3S)-malyl-CoA thioesterase. J. Bacteriol. 192 (2010) 1249-1258. [PMID: 20047909]

[EC created 2014]

Return to EC 3.1.2 home page
Return to EC 3.1 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page