IUBMB Enzyme Nomenclature


Accepted name: deoxyribonuclease I

Reaction: Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products

Other name(s): pancreatic DNase; DNase; thymonuclease, dornase; dornava; dornavac; pancreatic deoxyribonuclease; pancreatic dornase; deoxyribonuclease (pancreatic); pancreatic DNase; DNAase; deoxyribonucleic phosphatase; DNase I; alkaline deoxyribonuclease; alkaline DNase; endodeoxyribonuclease I; DNA depolymerase; Escherichia coli endonuclease I; deoxyribonuclease A; DNA endonuclease; DNA nuclease

Comments: Preference for double-stranded DNA. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9003-98-9


1. Privat de Garilhe, M. and Laskowski, M. Study of the enzymatic degradation of deoxyribonucleic acid by two different deoxyribonucleodepolymerases. J. Biol. Chem. 215 (1955) 269-276.

2. Kunitz, M. Isolation of crystalline deoxyribonuclease from beef pancreas. Science 108 (1948) 19-20.

3. Laskowski, M., Sr. Venom exonuclease, in Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 4, Academic Press, New York, 1971, pp. 313-328.

[EC created 1961 as EC, transferred 1978 to EC, modified 1981]

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