Reaction: Endonucleolytic cleavage to 5'-phosphomonoester
Other name(s): endoribonuclease H (calf thymus); RNase H; RNA*DNA hybrid ribonucleotidohydrolase; hybrid ribonuclease; hybridase; hybridase (ribonuclease H); ribonuclease H; hybrid nuclease; calf thymus ribonuclease H
Comments: Acts on RNA-DNA hybrids.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9050-76-4
References:
1. Haberkern, R.C. and Cantoni, G.L. Studies on a calf thymus ribonuclease specific for ribonucleic acid-deoxyribonucleic acid hybrids. Biochemistry 12 (1973) 2389-2395. [PMID: 4709937]
2. Stavrianopoulos, J.G. and Chargaff, E. Purification and properties of ribonuclease H of calf thymus. Proc. Natl. Acad. Sci. USA 70 (1973) 1959-1963. [PMID: 4516197]