IUBMB Enzyme Nomenclature


Accepted name: ribonuclease P

Reaction: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor

Other name(s): RNase P

Comments: An RNA-containing enzyme, essential for tRNA processing; generates 5'-termini or mature tRNA molecules.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 71427-00-4 (not distinguished from EC


1. Bikoff, E.K. and Gefter, M.L. In vitro synthesis of transfer RNA. I. Purification of required components. J. Biol. Chem. 250 (1975) 6240-6247. [PMID: 1099089]

2. Bikoff, E.K., La Rue, B.F. and Gefter, M.L. In vitro synthesis of transfer RNA. II. Identification of required enzymatic activities. J. Biol. Chem. 250 (1975) 6248-6255. [PMID: 1099090]

3. Robertson, H.D., Altman, S. and Smith, J.D. Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid presursor. J. Biol. Chem. 247 (1972) 5243-5251. [PMID: 4560501]

[EC created 1978, modified 1982]

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