IUBMB Enzyme Nomenclature


Accepted name: FMN hydrolase

Reaction: FMN + H2O = riboflavin + phosphate

Other name(s): FMN phosphatase; AtcpFHy1

Systematic name: FMN phosphohydrolase

Comments: Requires Mg2+. The enzyme, found in many isoforms purified from both bacteria and plants, is a member of the haloacid dehalogenase superfamily. Most of the isoforms have a wide substrate specificity [2], but isoforms specific for FMN also exist [3].

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Sandoval, F.J. and Roje, S. An FMN hydrolase is fused to a riboflavin kinase homolog in plants. J. Biol. Chem. 280 (2005) 38337-38345. [PMID: 16183635]

2. Kuznetsova, E., Proudfoot, M., Gonzalez, C.F., Brown, G., Omelchenko, M.V., Borozan, I., Carmel, L., Wolf, Y.I., Mori, H., Savchenko, A.V., Arrowsmith, C.H., Koonin, E.V., Edwards, A.M. and Yakunin, A.F. Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J. Biol. Chem. 281 (2006) 36149-36161. [PMID: 16990279]

3. Rawat, R., Sandoval, F.J., Wei, Z., Winkler, R. and Roje, S. An FMN hydrolase of the haloacid dehalogenase superfamily is active in plant chloroplasts. J. Biol. Chem. 286 (2011) 42091-42098. [PMID: 22002057]

[EC created 2016]

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