Reaction: trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate + H2O = trans,octacis-decaprenylphospho-β-D-ribofuranose + phosphate
Other name(s): Rv3807c (gene name)
Systematic name: trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate phosphohydrolase
Comments: The enzyme, studied from mycobacteria, in involved in the biosynthesis of trans,octacis-decaprenylphospho-β-D-arabinofuranose, which serves in those organisms as the arabinofuranose donor for the biosynthesis of the cell wall polymers arabinogalactan and lipoarabinomannan.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Wolucka, B.A. Biosynthesis of D-arabinose in mycobacteria - a novel bacterial pathway with implications for antimycobacterial therapy. FEBS J. 275 (2008) 2691-2711. [PMID: 18422659]
2. Jiang, T., Cai, L., Zhao, X., He, L., Ma, Y., Zang, S., Zhang, C., Li, X. and Xin, Y. Functional identification of MSMEG_6402 protein from Mycobacterium smegmatis in decaprenylphosphoryl-D-arabinose biosynthesis. Microb Pathog 76 (2014) 44-50. [PMID: 25223716]