Reaction: 4'-phosphooxetanocin A + H2O = oxetanocin A + phosphate
Glossary: 4'-phosphooxetanocin A = [(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate
Other name(s): oxsA (gene name)
Systematic name: [(2S,3R,4R)-4-(6-aminopurin-9-yl)-3-(hydroxymethyl)oxetan-2-yl]methyl phosphate phosphohydrolase
Comments: The enzyme can catalyse the sequential hydrolysis of tri-, di-, and mono-phosphorylated oxetanocin A compounds, releasing one molecule of inorganic phosphate at a time. The active site switches from a dinuclear to a mononuclear metal center as phosphates are eliminated from the substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Bridwell-Rabb, J., Zhong, A., Sun, H.G., Drennan, C.L. and Liu, H.W. A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis. Nature 544 (2017) 322-326. [PMID: 28346939]