Reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate
For diagram of reaction click here.
Other name(s): acylneuraminate 9-phosphatase; N-acylneuraminic acid 9-phosphate phosphatase; N-acylneuraminic (sialic) acid 9-phosphatase
Systematic name: N-acylneuraminate-9-phosphate phosphohydrolase
Comments: The enzyme, found in vertebrates, is equally active with N-acetylneuraminate 9-phosphate and N -glycoloylneuraminate 9-phosphate.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37288-13-4
References:
1. Jourdian, G.W., Swanson, A.L., Watson, D., and Roseman S. Isolation of sialic acid 9-phosphatase from human erythrocytes. J. Biol. Chem. 239 (1964) PC2714–PC2716.[PMID: 14235556]
2. Jourdian, G.W., Swanson, A., Watson, D. and Roseman, S. N-Acetylneuraminic (sialic) acid 9-phosphatase. Methods Enzymol. 8 (1966) 205-208.
3. Maliekal, P., Vertommen, D., Delpierre, G. and Van Schaftingen, E. Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase. Glycobiology 16 (2006) 165–172. [PMID: 16237198]