Reaction: [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O = [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate
For diagram click here.
Other name(s): reductase phosphatase
Systematic name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase
Comments: Acts on the product of the reaction catalysed by EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, simultaneously dephosphorylating and activating EC 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 73507-97-8
References:
1. Gil, G. and Hegardt, F.G. Some properties of purified 3-hydroxy-3-methylglutaryl coenzyme A reductase phosphatases from rat liver. Arch. Biochem. Biophys. 214 (1982) 192-198. [PMID: 6282220]
2. Gil, G., Sitges, M. and Hegardt, F.G. Purification and properties of rat liver hydroxymethylglutaryl coenzyme A reductase phosphatases. Biochim. Biophys. Acta 663 (1981) 211-221. [PMID: 6260210]