Reaction: [a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate
Other name(s): phosphotyrosine phosphatase; phosphoprotein phosphatase (phosphotyrosine); phosphotyrosine histone phosphatase; protein phosphotyrosine phosphatase; tyrosylprotein phosphatase; phosphotyrosine protein phosphatase; phosphotyrosylprotein phosphatase; tyrosine O-phosphate phosphatase; PPT-phosphatase; PTPase; [phosphotyrosine]protein phosphatase; PTP-phosphatase
Systematic name: protein-tyrosine-phosphate phosphohydrolase
Comments: Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC EC 220.127.116.11 non-specific protein-tyrosine kinase.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 79747-53-8
1. Foulkes, J.G., Howard, R.F. and Ziemiecki, A. Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine. FEBS Lett. 130 (1981) 197-200. [PMID: 6169552]
2. Gallis, B., Bornstein, P. and Brautigan, D.L. Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells. Proc. Natl. Acad. Sci. USA 78 (1981) 6689-6693. [PMID: 6273884]