IUBMB Enzyme Nomenclature


Accepted name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

Reaction: phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate

For diagram click here.

Glossary: inositol 1,4,5-trisphosphate = Ins(1,4,5)P3
inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3

Other name(s): PTEN (gene name), MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase

Systematic name: 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase

Comments: Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 210488-47-4


1. Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y. Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus. Eur. J. Biochem. 238 (1996) 350-356. [PMID: 8681945]

2. Maehama, T. and Dixon, J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375-13378. [PMID: 9593664]

[EC created 1999, modified 2002]

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