IUBMB Enzyme Nomenclature


Accepted name: adenosylcobalamin/α-ribazole phosphatase

Reaction: (1) adenosylcobalamin 5'-phosphate + H2O = coenzyme B12 + phosphate
(2) α-ribazole 5'-phosphate + H2O = α-ribazole + phosphate

For diagram of the reaction click here

Other name(s): CobC; adenosylcobalamin phosphatase; α-ribazole phosphatase

Systematic name: adenosylcobalamin/α-ribazole-5'-phosphate phosphohydrolase

Comments: This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 251991-06-7


1. O'Toole, G.A., Trzebiatowski, J.R. and Escalante-Semerena, J.C. The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. J. Biol. Chem. 269 (1994) 26503-26511. [PMID: 7929373]

2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B12). Nat. Prod. Rep. 19 (2002) 390-412. [PMID: 12195810]

3. Zayas, C.L. and Escalante-Semerena, J.C. Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway. J. Bacteriol. 189 (2007) 2210-2218. [PMID: 17209023]

[EC created 2004, modified 2011]

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