IUBMB Enzyme Nomenclature


Accepted name: mannosylfructose-phosphate phosphatase

Reaction: β-D-fructofuranosyl-α-D-mannopyranoside 6F-phosphate + H2O = β-D-fructofuranosyl-α-D-mannopyranoside + phosphate

Glossary: mannosylfructose = β-D-fructofuranosyl-α-D-mannopyranoside

Other name(s): mannosylfructose-6-phosphate phosphatase; MFPP

Systematic name: β-D-fructofuranosyl-α-D-mannopyranoside-6F-phosphate phosphohydrolase

Comments: This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ for activity. Mannosylfructose is the major endogenous osmolyte produced by several α-proteobacteria in response to osmotic stress and is synthesized by the sequential action of EC (mannosylfructose-phosphate synthase) followed by this enzyme. While mannosylfructose 6-phosphate is the physiological substrate, the enzyme can use sucrose 6-phosphate very efficiently. The F in mannosylfructose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Torres, L.L. and Salerno, G.L. A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases. Proc. Natl. Acad. Sci. USA 104 (2007) 14318-14323. [PMID: 17728402]

[EC created 2009]

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