IUBMB Enzyme Nomenclature


Accepted name: D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphatase

Reaction: D-glycero-α-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-α-D-manno-heptose 1-phosphate + phosphate

Other name(s): gmhB (gene name)

Systematic name: D-glycero-α-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase

Comments: The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the α-anomer than with the β-anomer [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wang, L., Huang, H., Nguyen, H.H., Allen, K.N., Mariano, P.S. and Dunaway-Mariano, D. Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). Biochemistry 49 (2010) 1072-1081. [PMID: 20050615]

[EC created 2010]

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