IUBMB Enzyme Nomenclature


Accepted name: 3',5'-nucleoside bisphosphate phosphatase

Reaction: nucleoside 3',5'-bisphosphate + H2O = nucleoside 5'-phosphate + phosphate

Systematic name: nucleoside-3',5'-bisphosphate 3'-phosphohydrolase

Comments: The enzyme, characterized from the bacterium Chromobacterium violaceum, has similar catalytic efficiencies with all the bases. The enzyme has similar activity with ribonucleoside and 2'-deoxyribonucleoside 3',5'-bisphosphates, but shows no activity with nucleoside 2',5'-bisphosphates (cf. EC, 3'(2'),5'-bisphosphate nucleotidase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Cummings, J.A., Vetting, M., Ghodge, S.V., Xu, C., Hillerich, B., Seidel, R.D., Almo, S.C. and Raushel, F.M. Prospecting for unannotated enzymes: discovery of a 3',5'-nucleotide bisphosphate phosphatase within the amidohydrolase superfamily. Biochemistry 53 (2014) 591-600. [PMID: 24401123]

[EC created 2015]

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