IUBMB Enzyme Nomenclature


Accepted name: IMP-specific 5'-nucleotidase

Reaction: IMP + H2O = inosine + phosphate

Other name(s): ISN1 (gene name)

Systematic name: inosine 5'-phosphate phosphohydrolase

Comments: The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Itoh, R. Purification and some properties of an IMP-specific 5'-nucleotidase from yeast. Biochem. J. 298 (1994) 593-598. [PMID: 8141771]

2. Itoh, R., Saint-Marc, C., Chaignepain, S., Katahira, R., Schmitter, J.M. and Daignan-Fornier, B. The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase. BMC Biochem. 4 (2003) 4. [PMID: 12735798]

[EC created 2016]

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