IUBMB Enzyme Nomenclature


Accepted name: phospholipase D

Reaction: A phosphatidylcholine + H2O = choline + a phosphatidate

Other name(s): lipophosphodiesterase II; lecithinase D; choline phosphatase

Systematic name: phosphatidylcholine phosphatidohydrolase

Comments: Also acts on other phosphatidyl esters.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9001-87-0


1. Astrachan, L. The bond hydrolyzed by cardiolipin-specific phospholipase D. Biochim. Biophys. Acta 296 (1973) 79-88. [PMID: 4632675]

2. Einset, E. and Clark, W.L. The enzymatically catalyzed release of choline from lecithin. J. Biol. Chem. 231 (1958) 703-715.

3. Hanahan, D.J. and Chaikoff, I.L. On the nature of the phosphorus-containing lipides of cabbage leaves and their relation to a phospholipide-splitting enzyme contained in these leaves. J. Biol. Chem. 172 (1948) 191-198.

4. Tookey, H.L. and Balls, A.K. Plant phospholipase D. I. Studies on cottonseed and cabbage phospholipase D. J. Biol. Chem. 218 (1956) 213-224.

[EC created 1961]

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