IUBMB Enzyme Nomenclature


Accepted name: sphingomyelin phosphodiesterase D

Reaction: sphingomyelin + H2O = ceramide phosphate + choline

Other name(s): sphingomyelinase D

Systematic name: sphingomyelin ceramide-phosphohydrolase

Comments: Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 54992-31-3


1. Carne, H.R. and Onon, E. Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels. Nature 271 (1978) 246-248. [PMID: 622164]

2. Soucek, A., Michalec, C. and Souckov, A. Identification and characterization of a new enzyme of the group phospholipase D isolated from Corynebacterium ovis. Biochim. Biophys. Acta 227 (1971) 116-128. [PMID: 5543581]

[EC created 1978]

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