IUBMB Enzyme Nomenclature


Accepted name: glycerophosphoinositol inositolphosphodiesterase

Reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate

For diagram click here.

Other name(s): 1,2-cyclic-inositol-phosphate phosphodiesterase; D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase; D-inositol 1,2-cyclic phosphate 2-phosphohydrolase; D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase; 1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase; inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase

Systematic name: 1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase

Comments: This enzyme also hydrolyses Ins(cyclic 1,2)P to Ins-1-P

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9076-91-9 (from EC, 72414-13-2 (not distinguished from EC


1. Dawson, R.M.C. and Hemington, N. A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol. Biochem. J. 162 (1977) 241-245. [PMID: 192216]

2. Dawson, R.M.C. and Clarke, N.G. D-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase. Biochem. J. 127 (1972) 113-118. [PMID: 4342209]

3. Dawson, R.M.C. and Clarke, N.G. A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney. Biochem. J. 134 (1973) 59-67. [PMID: 4353088]

4. Ross, T.S. and Majerus, P.W. Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate. J. Biol. Chem. 266 (1991) 851-856. [PMID: 1845995]

[EC created 1984, (EC created 1976, incorporated 2002), modified 2002]

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