IUBMB Enzyme Nomenclature


Accepted name: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase

Reaction: (1) 5-phospho-α-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate

Other name(s): cyclic phosphate dihydrolase; phnPP (gene name)

Systematic name: 5-phospho-α-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase

Comments: The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ghodge, S.V., Cummings, J.A., Williams, H.J. and Raushel, F.M. Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus. J. Am. Chem. Soc. 135 (2013) 16360-16363. [PMID: 24147537]

[EC created 2014]

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